This practical handbook seeks to update the clinician with clinically relevant advances in this field. The first two chapters discuss the new WHO guidelines for semen analysis and the use of special tests to assess sperm function, especially DNA integrity. Subsequent chapters address the uncommon but frustrating practical problem of ejaculatory failure, the treatment of OATS through medical and surgical therapy, and the clinical approach to the evaluation and management for azoospermia—a subject of increasing importance.