There are 107 chapters with about 100 figures and 72 tables. These large numbers of tables and figures have been used so that the information is easily understood and reading is facilitated. The update consists of 31 sections and each part discusses a group of disorders. Diabetes is the fulcrum of each chapter. Commencing with the epidemiology and pathogenesis, moving on to molecular mechanisms, clinical manifestations across the ages, with a focus on diabetes in women including gestational, secondary, and prediabetes, obesity, screening, diagnosis, self-monitoring of blood glucose, complete management with medical nutrition therapy, artificial sweeteners, exercise, injectable and oral agents, in special situations, glycemic emergencies and variability; treatment issues, role of nutrients, microvascular complications, novel markers, diabetic foot, hypertension, dyslipidemia, sleep and stress, sexual dysfunction, tuberculosis , rheumatological, musculoskeletal, thyroid, liver disorders, socioeconomic aspects, infertility, addiction, education, research, recent advances, hypoglycemia, role of the government, private sector, and industry and using stem cells and system biology to tackle diabetes in the 21st century have all been well covered.