Clinical Focus series on fibroids is an illustrious manual about all the practical aspects for managing various pertinent challenges in day-to-day gynecological practice. Uterine fibroids, or leiomyomas, are the most prevalent benign tumors in women of reproductive age. Their effects range from subfertility and abnormal uterine bleeding (AUB) to significant psychological and sexual dysfunction, underscoring the urgent need for thorough understanding and effective management. This clinical focus will not only help young clinicians for a ready -reckoner but also for seniors to update the topic with recent guidelines. This series begin with an exploration of the epidemiology and risk factors of fibroids, laying a foundation for clinicians to understand their varied presentations. Series then delve into the classification of fibroid uterus, facilitating accurate diagnosis and personalized treatment strategies based on size, location, and symptoms. Key diagnostic tools, such as ultrasound assessment, are highlighted for their critical role in distinguishing fibroids from other uterine conditions. The series also examines the intricate link between fibroids and subfertility, emphasizing their impact on reproductive health. Comprehensive management strategies for fibroids are explored, from medical management and pre-surgical hormonal treatments to various surgical interventions, including laparoscopic, abdominal, and hysteroscopic myomectomy. Special attention is given to complex scenarios, including recurrent fibroids, wandering and cervical fibroids, and challenges during cesarean sections. The series also addresses rare conditions like stromal tumors of uncertain malignant potential (STUMP) and atypical leiomyoma (ALM), providing clinicians with valuable insights into these complex issues. All the chapters have been thoroughly updated by incorporating guidelines and recent advances. By presenting a holistic approach to fibroid management, this series aims to enhance clinical practice, improve patient outcomes, and support the ongoing education of healthcare professionals dedicated to women’s health.