This handbook provides an up-to-date strategies in sepsis management among physicians, surgeons, anaesthetists & critical care trainee. The book caters to the need of understanding sepsis evolution, various early diagnosis techniques, management aspects & future therapies. This book has 6 sections & 23 Chapters written by eminent experienced faculties from the field of infectious diseases, microbiology & critical care medicine . Emphasis has been attributed to Applied Pathophysiology of sepsis, Initial presentation , diagnosis, Organ dysfunction and support, Antimicrobials in sepsis . and Adjunctive therapies in sepsis.