Surgery is the expertise of human anatomical knowledge and applied surgical skills to remove or repair the body part. A surgical practical examination is a subjective clinical assessment of the postgraduate student. This OSCE in Clinical Surgery is dedicated to DNB General Surgery final exam-going students and post-MS General Surgery candidates who are going to take the DNB final exit examination for a comprehensive understanding of the objective structured clinical examination (OSCE) pattern, which is an integral part of the DNB surgery broad specialty exit examination. We tried to design the questions and answers, including a variety of clinical scenarios and clinical pictures from the standard reference books, to introduce the students with the OSCE pattern of examination so that they can prepare accordingly, it is not meant to cover the whole syllabus. We heartily welcome all your insightful suggestions and criticism for the enhancement and refinement of our knowledge.