This book on Common Clinical Challenges—A Treatise on Maladies and Remedies is an exposition of common medical encounters in day-to-day practice, by an author with varied experience of about five decades, right from the days of clinical student of medicine, house officer, postgraduate student, tutor, assistant professor, professor/head, Department of Medical Institutions. There has been an active involvement in the training programmes for undergraduates and postgraduates and committed patient care, all through these years continuously are rich contributing factors in this endeavour. This manual is a practical clinical guide to diagnosis and principles of treatment of some of the age-old medical problems. The pattern followed for each symptom runs through basic fundamental concepts, appended causes, essentials of diseases therein, clinical approach with illustrations wherever necessary and diagnostic flow charts followed by symptomatic as well as specific treatment. This is not a textbook of description of diseases to bestow theoretical knowledge, but an attempt to bridge the gap between theory and practice of medicine and reinforce the ability to apply the knowledge coherently to various clinical situations. The idea of writing such a symptom-oriented-approach book is a real challenge to one who has spent most of his life in the practice of medicine facing ever so many specific problem areas. I hope all the thirty-six symptoms, specially identified in relation to day-to-day practice of general medicine, some of which even poorly understood, are presented with lucidity, in a practical and clinically useful manner, for medical personnel at any stage ranging from an examination performing student to a practitioner, or even a mature physician for that matter.