The main focus of the book “Advances in CNS Demyelinating Disorders”, is to provide a comprehensive understanding of the management principles across the spectrum of CNS demyelinating disorders such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), myelin oligodendrocyte glycoprotein associated disease (MOGAD), and other seronegative entities. Each chapter delves into the multifaceted nature of these disorders, highlighting advances in research and clinical care while acknowledging the challenges that persist in their management. This book is intended for clinicians and students who are striving to better understand and manage CNS demyelinating disorders. While significant progress has been made in improving outcomes for patients, much work remains to be done, particularly in areas of individualized treatment and long-term care strategies.