The sixth edition of this treatise comes little more than 6 years after the fifth edition and its publication had to endure the challenges of the COVID period (2020–2022) when almost nothing beyond mundane items moved. While the basic structure of the book has been retained, all the chapters have been updated to incorporate as many recent developments in diagnostic and therapeutic modalities as possible. Considering the breakneck speed at which cardiology and allied specialties of medicine are progressing, there are bound to be some omissions for which the editor begs to be pardoned.