A Comprehensive Guide for Physicians addresses the growing global burden of metabolic dysfunction-associated steatotic liver disease (MASLD), a condition closely linked to obesity, diabetes, and metabolic syndrome. Designed for everyday clinical use, this evidence-based guide covers the full spectrum of MASLD—from its historical evolution and pathophysiology to diagnosis, treatment, and long-term management—integrating the latest guidelines and therapies, including emerging agents like resmetirom and GLP-1 agonists. It provides practical tools such as non-invasive diagnostics (FIB-4, elastography, MRI-PDFF), risk stratification algorithms, and detailed approaches for special populations including children, pregnant women, and those with cirrhosis or hepatocellular carcinoma. Emphasizing a multidisciplinary and personalized care model, the book also explores public health strategies, cost-effective screening, and healthcare implications in both Indian and global contexts.