The protection of human skin against the relentless assault of ultraviolet radiation has evolved dramatically over recent decades. Sunscreens are now recognized as critical instruments in dermatological health and are pivotal in preventing photodamage, premature aging, and skin cancers. As our understanding of the science underpinning sunscreen formulations advances, so too does the importance of disseminating accurate, evidence-based knowledge to both clinicians and the general public. Additionally, the increasing influence of social media has amplified both awareness and misconceptions about sunscreen use, making it imperative to provide clear and evidence-based guidance. A wide variety of sunscreen products, tailored for distinct age groups ranging from children to the elderly, is currently available in the market. However, a substantial gap persists regarding clear, scientifically validated information to guide appropriate selection and use. “Sunscreen Science: Formulations, Efficacy and Best Practices” has been meticulously compiled to bridge this gap, presenting a balanced approach that blends rigorous scientific understanding with practical considerations. Each chapter offers an in-depth exploration of vital aspects ranging from the molecular mechanisms of ultraviolet protection to regulatory landscapes, safety evaluations, and formulation challenges. This book delivers comprehensive insights into sunscreen development and its pivotal role in photoprotection. This work not only serves as a reliable reference for clinicians, researchers, and industry professionals but also empowers readers with clarity and depth, fostering informed choices about skin protection. Just as the sun illuminates and guides us, may “Sunscreen Science: Formulations, Efficacy and Best Practices” serve as a beacon, guiding readers toward greater understanding, healthier practices, and informed decisions in the pursuit of knowledge and skin health.