This book, “AI in Medicine: Clinical Updates & Physician Perspectives”, is the culmination of collaborative efforts from global physician leaders, AI experts, and educators committed to responsibly shaping the next frontier of healthcare. Our goal was simple yet ambitious: To present a physician-led, evidence-based, and multidisciplinary textbook that reflects real-world AI applications in medicine and prepares healthcare professionals for a digital future. From primary care to highly specialized fields like endocrinology, pediatrics, radiology neuropsychiatry, clinical pharmacology, and many more, this book provides readers with clinical updates, practical guidance, and case-based insights. Importantly, it also includes chapters on core AI principles, responsible deployment, education and training, and generative AI—all written by clinicians who have been active in both AI implementation and medical practice. This textbook is also a reflection of the vision of Doctors AI, a growing movement of clinicians upskilling for the AI era.